The Science of Semaglutide: How It Works in Diabetes Management

Semaglutide is praised as a promising and helpful treatment for diabetes and obesity. But you might wonder, how does it work and what are the things to keep in mind? Well, don't worry! We put together a guide covering everything you need about semaglutide.

Tayyaba Hassan
July 20, 2023

In this guide, we'll explain what semaglutide is, how it works, the recommended dosage, and possible side effects and give you an idea of ​​how much it might cost. So, please sit back, relax, and let us fill you in on all the essential details about semaglutide!

What is Semaglutide? And Semaglutide mechanism of action.

Semaglutide peptide is part of a class of drugs called GLP-1 receptor agonists. These drugs stimulate GLP-1, a hormone naturally released into your stomach when you eat.

GLP-1 has a couple of essential functions in our body. First, it tells your body to produce more insulin, which helps maintain your blood sugar levels. It's like a little helper to your body's sugar regulation team.

How does semaglutide work for weight loss? GLP-1 (Semaglitide) also interacts with specific parts of your brain that regulate your appetite and make you feel full. High levels of GLP-1 can help control your cravings and let your brain know you've had enough. It's like a little switch that tells your brain, "Hey, I'm full!"

So, in a nutshell, the semaglutide mechanism of action is like GLP-1 in your body. It helps maintain your blood sugar levels by boosting insulin levels, and it also helps regulate your cravings and makes you feel better for longer. It's a great way to control sugar and satisfy your hunger!

What does semaglutide do?

Semaglutide as Ozempic

Well, let me break it down for you. Semaglutide injections, also known as Ozempic, have some important uses.

First, it is used in adults with type 2 diabetes. You know, that situation where the body has trouble controlling blood sugar levels by regulating insulin. Semaglutide oral is prescribed when the body fails to maintain blood sugar levels independently. It sounds like another alternate way to help your body manage diabetes.

But that's not all! Semaglutide injections are also used for adults with type 2 diabetes who have cardiovascular disease. It can help reduce the risk of stroke, heart disease, or death. It's a bit like a guardian angel checking on your heart health. Now, it's important to note that semaglutide injections are not indicated for type 1 diabetes or a condition called diabetic ketoacidosis. It is specially designed for type 2 diabetes.


IMG Source: Gethealthybenefits

Semaglutide as Wegovi

Another Semaglutide injections, called Wegovi (semaglutide for weight loss in non diabetics). Semaglutide may also be used in obese children 12 years of age or older as part of an individual diet and exercise program to help them lose weight.

How does semaglutide work?

Semaglutide peptide belongs to a class of medicines called incretin mimetics. Control blood sugar levels, and help the pancreas produce adequate insulin amounts. Insulin then helps carry sugar from the blood to other energy-using tissues. Semaglutide also slows food movement through the stomach, decreasing appetite and promoting weight loss.

After all, using semaglutide, lifestyle changes such as diet, exercise, and monitoring blood sugar levels can help manage diabetes. It improves your health and prevents heart disease, stroke, kidney problems, nerve damage, and eye problems.

How should this product be used?

Let's go into it step by step.

Semaglutide injections are liquid suspensions that come in pre-filled doses. You will need to apply it to your skin.

Semaglutide is injected about once a week, with or without a meal. You can choose any day of the week that works for you and can do that at any time. Is it easy?

If you want to change the day you take semaglutide, that's perfectly fine. Just make sure it has been at least 2 days (48 hours) since the last Semaglutide dose. Keep things tidy, but keep it a little simple.

Following the instructions on your medicine label is very important. Feel free to ask your doctor or pharmacist for help if something needs to be clarified. You should make sure you use semaglutide injections as directed. Do not use more or less or more than your doctor directs.

Always check the solution carefully before using semaglutide. It should be clear, colourless, and free of particles. Do not use it if it has a different appearance, such as being coloured, cloudy, hard, or with particles, or if the packaging says it is expired.

Semaglutide Dosing

Let's talk about the dosage of this drug. Remember, doses can vary for different patients, so following your doctor's semaglutide prescription or directions on the label is essential. This article will give you some general information but do not change your dosage unless your doctor advises.

The amount of semaglutide injection you take depends on your strength. The number of doses you take each day, the interval between doses, and the duration will also be determined by the specific medical issue you are dealing with.

For type 2 diabetes and to reduce the risk of heart attack or stroke, if you use Ozempic injections:

  • Adults = You typically start with 0.25 milligrams (mg) as a subcutaneous injection once weekly for 4 weeks. Your doctor may adjust the Semaglutide dose as needed, but generally, at most, 2 mg at a time per week.

  • Children = dosage should be determined by your doctor.

When you start using semaglutide, your doctor may start with a lower dose. After 4 weeks, your dose may be increased depending on how your body responds to the medication. Also, after another 4 weeks, the dosage can be adjusted again. It's all about making the right amount for yourself.

Remember that semaglutide injections are not a cure-all for diabetes or semaglutide weight loss. Even if you start to feel better, keep using it as directed.

Note: Do not stop using semaglutide without first talking to your doctor.

Be sure to read the instructions for use that come with the product. Appropriate semaglutide dose for weight loss will be instructed on it. Your pharmacist or physician can help you if you have questions.

How to inject semaglutide?

To take a semaglutide injection, you must give a shot to your stomach, thighs, or upper arms. Just remember to use a different position on your body for each shot. It is important to rotate spots so as not to overuse one space. If you use insulin, ensure you don’t mix in the same syringe. Take them separately.


IMG source: Gethealthybenefits

How To Store Semaglutide?

People usually ask does semaglutide need to be refrigerated. Here are essential guidelines for storing and disposing of semaglutide.

  • Keep semaglutide oral and all medications out of the reach of children. It is important to ensure their safety.

  • Do not store any expired or unused medicines. Consult your healthcare professional on the best way to dispose of medications you no longer need.

  • Store semaglutide in the refrigerator, but be sure not to freeze it. Freezing can affect the efficacy of the product.

  • If you have a new, unused medicine pen, store it in the refrigerator in its original packaging. Remember not to freeze it. 

Ozempic pens

Store them in the refrigerator or at room temperature for up to 56 days.

Wegovy pens

You can store them in the refrigerator or at room temperature for up to 28 days. After the mentioned time, discard the pen in case any medicine remains.

Some important reminders

  • Never reuse needles of semaglutide again, and never share needles or pens.

  • Used needles should be disposed of in a puncture-resistant container to avoid needle sticking.

  • Keep this product out of the reach of children and pets.

  • If you need help with this, ask your doctor or pharmacist for guidance.

By following these guidelines, you can ensure that medicines that contain semaglutide are appropriately stored and disposed of safely.

Precautions

Here are some important precautions to keep in mind when using semaglutide peptide.

  • Tell your doctor about any medications, vitamins, supplements, and herbs you are taking or plan to take. It is especially important because semaglutide can affect your body's absorption of other oral medications.

  • Tell your doctor and pharmacist if you are allergic to semaglutide or similar medications. Or if you are allergic to any ingredients in semaglutide. If necessary, they can give you a list of ingredients.

  • Tell your doctor if you have pancreatitis (inflammation of the intestines), diabetic retinopathy (eye damage due to diabetes), gallbladder disease, or kidney disease.

  • Tell your doctor if you have recently had a seizure, stroke, vomiting, or inability to drink water, as these conditions can cause dehydration.

  • See your doctor if you've had a significant change in your diet, exercise routine, or weight, or if you're sick, have an infection or cold, unusual stress, or an injury. Those things may affect your blood sugar levels, and adjusting your semaglutide dosage may be necessary.

  • Be aware that using semaglutide for weight loss may affect your mood. In some cases, unexpected changes may occur, including suicidal thoughts. It is important to consult your doctor immediately if you experience symptoms such as depression.

  • If you are planning to become pregnant, your doctor may advise you to stop semaglutide injections for 2 months before trying to conceive. It is important to discuss your pregnancy plans with your doctor.

  • Tell your doctor if you are currently pregnant or breastfeeding. Semaglutide will be indicated for use at these times. 

You can use semaglutide safely and effectively by taking these precautions and informing your doctor.

Semaglutide Side Effects

Here are some semaglutide long term side effects you should let your doctor know about right away:

  • Allergic reactions: If you have skin irritation, itching, burning sensation, or swelling of your mouth, lips, tongue, or throat. It could make you uncomfortable, and you should report it immediately.

  • Vision changes: If you notice any changes in your vision, it's important to notify your care team.

  • Dehydration: Signs of dehydration, such as increased thirst, dry mouth, lightheadedness, and dizziness. Having yellow or dark brown urine, report your doctor as soon as possible.

  • Gallbladder problems: Severe abdominal pain, nausea, vomiting, and fever can be symptoms of gallbladder problems. If you notice these symptoms, let your care team know.

  • Increased heart Beat: If your heart rate is fast, palpitating, or abnormal, it's important to notify your healthcare specialist as soon as possible.

  • Kidney Injury: Decreased urine output and swelling in the ankles, arms, or legs may indicate kidney injury. Be sure to report these symptoms to your doctor.

  • Pancreatitis: Severe abdominal pain that circulates to your back. The pain worsens after eating, and fever, nausea, and vomiting can be symptoms of pancreatitis and should be reported immediately.

  • Thyroid cancer: It is important to consult your doctor if you notice a lump in your throat, experience pain or difficulty swallowing, have difficulty breathing, or notice hoarseness.

Some semaglutide side effects usually don't require immediate treatment, but you should inform your doctor if they persist.

  • Loss of appetite

  • Diarrhea

  • Abdominal pain

  • Nausea

  • Cough

  • Weight Loss

Please keep in mind that this list may not cover all side effects of semaglutide. If you have any concerns or experience unusual symptoms, do not hesitate to contact your doctor for medical advice. You can also report it to FDA at 1-800-FDA-1088.

Disclaimer: 

This article is a summary. It may only cover some possible information. Talk to your doctor, pharmacist, or healthcare provider if you have more questions about this medicine.


FAQs

Are there any semaglutide weight loss side effects?

Semaglutide for weight loss can cause dizziness, fatigue, and digestive problems like diarrhea, constipation, and gastric issues.

How long do semaglutide side effects last?

The most common side effects of semaglutide are nausea, vomiting, and diarrhea, which usually improve within a few weeks. However, there are rare but serious semaglutide injection side effects, such as diarrhea and constipation, that may require immediate treatment.

Is semaglutide safe?

Semaglutide appears safe in the short to medium term based on trials. However, like any medication, there are side effects to watch out for.

Does semaglutide make you tired?

Ozempic (semaglutide) rarely causes fatigue in some individuals, but this usually improves over time.

Is semaglutide the same as ozempic?

Both Wegovi and Ozempic contain semaglutide. The ingredient is the same, but it is not the same medication. They have similar features but serve different purposes. Wegovi is specifically approved for weight management, while Ozempic is primarily used to treat type 2 diabetes. So, although they have the same active ingredient (semaglutide), they are different drugs with different names and uses.

How long does it take for semaglutide to work?

It usually takes about 8-12 weeks of continuous use for semaglutide to show its effects.

Why am I not losing weight on semaglutide?

If you are not losing weight on semaglutide, maybe you need a higher dosage. Ask your doctor or pharmacist for guidance.


Share this post

Recommended

Subscribe to new posts